AP1S1 and AP2A2

Number of citations of the paper that reports this interaction (PubMedID 11707398)
30

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		AP1S1	AP2A2
Description		adaptor related protein complex 1 subunit sigma 1	adaptor related protein complex 2 subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Golgi Apparatus Cytosol Clathrin-coated Pit Membrane AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Ficolin-1-rich Granule Membrane
	Molecular Function	Clathrin Adaptor Activity	Molecular_function Protein Binding Lipid Binding Protein Kinase Binding Clathrin Adaptor Activity Disordered Domain Specific Binding Cargo Adaptor Activity
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Response To Virus Vesicle-mediated Transport	Intracellular Protein Transport Receptor-mediated Endocytosis Clathrin-dependent Endocytosis
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Adult body size ( 32376654) Serum metabolite concentrations in chronic kidney disease ( 33838163)	Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)
Interacting Genes		7 interacting genes: AP1G1 AP1G2 AP1M2 AP2A2 PICK1 RHOU TNFRSF9	22 interacting genes: AAGAB AMPH AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT ILK KCNQ1DN LRPPRC NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC ZPR1
Entrez ID		1174	161
HPRD ID		04635	06256
Ensembl ID		ENSG00000106367	ENSG00000183020
Uniprot IDs		A0A024QYT6 P61966	O94973
PDB IDs		4P6Z
Enriched GO Terms of Interacting Partners?
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