PARK7 and DAXX

Number of citations of the paper that reports this interaction (PubMedID 15983381)
104

Data Source:
HPRD (in vitro)

		PARK7	DAXX
Description		Parkinsonism associated deglycase	death domain associated protein
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction PML Body Axon Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Chromosome, Centromeric Region Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body PML Body
	Molecular Function	Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity MRNA Binding Signaling Receptor Binding Copper Ion Binding Protein Binding Transcription Factor Binding Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Oxygen Sensor Activity Enzyme Binding Kinase Binding Cytokine Binding Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Protein Deglycase Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Cadherin Binding Mercury Ion Binding Androgen Receptor Binding Peroxiredoxin Activity Scaffold Protein Binding DNA-binding Transcription Factor Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein N-terminus Binding Androgen Receptor Binding Sumo-dependent Protein Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus DNA Repair Negative Regulation Of Protein Kinase Activity Proteolysis Protein Deglycosylation Autophagy Inflammatory Response Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Methylglyoxal Metabolic Process Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Histone Modification Lactate Biosynthetic Process Insulin Secretion Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TRAIL Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Histone Ubiquitination Negative Regulation Of Protein Sumoylation Positive Regulation Of NAD(P)H Oxidase Activity Cellular Response To Oxidative Stress Regulation Of Histone Acetylation Cellular Response To Glyoxal Peptidyl-cysteine Deglycation Peptidyl-arginine Deglycation Peptidyl-lysine Deglycation Protein Deglycation, Glyoxal Removal Protein Deglycation, Methylglyoxal Removal Glutathione Deglycation Glucose Homeostasis Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Membrane Hyperpolarization Negative Regulation Of Cell Death Regulation Of Androgen Receptor Signaling Pathway Methylglyoxal Catabolic Process To Lactate Cellular Response To Hydrogen Peroxide Detection Of Oxidative Stress Cellular Oxidant Detoxification Guanine Deglycation Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Cellular Detoxification Of Aldehyde Cellular Detoxification Of Methylglyoxal Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Protein Acetylation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Metabolic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Positive Regulation Of L-dopa Decarboxylase Activity Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Androgen Receptor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Cellular Response To Heat Cellular Response To Unfolded Protein Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Positive Regulation Of Neuron Death Cellular Response To Sodium Arsenite
Pathways		SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Drugs		Copper
Diseases
GWAS		Behcet's disease ( 33393726) Blood protein levels ( 30072576) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Ulcerative colitis ( 28067908 21297633)	Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		26 interacting genes: BAX BBS1 BCL2L1 CASP8 CSN1S1 DAXX EFCAB6 FADD GOPC GPX4 HIPK1 HSPA5 MAPK8IP1 MAPKAPK5 NDUFA4 PIAS2 PINK1 POLE2 PPP2R1A PPP2R1B PRKACA SNCA SOD1 SUMO1 UBA2 UBE2I	123 interacting genes: ACVR2A ADGRF3 AIRE AMOTL2 AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CDSN CENPC CEP63 CEP70 CFLAR COL11A2 CREBBP CSNK2A1 DAPK3 DKC1 DMAP1 DNMT1 DXO ESRRG ETS1 FAM9B FANCA FAS FASLG FBXO25 FTH1 GAS8 GNL1 GOLGA2 GOLGA6L9 GRIPAP1 GTF2H4 H2BC15 H3-3B H3-5 H3C3 H4-16 H4C6 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 IKBKE KCTD4 MAP3K5 MCRS1 MDM2 MEN1 MIPOL1 MKRN1 MSANTD4 MX1 MYH11 NECAB2 NRG2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PIBF1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RASSF3 RIPK3 RNF4 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SQSTM1 SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TAX1BP1 TCF3 TCF4 TCF7L2 TFIP11 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TRIM54 TSG101 UBC UBE2I USH1G USP7 ZBTB2 ZBTB26
Entrez ID		11315	1616
HPRD ID		03961	04424
Ensembl ID		ENSG00000116288	ENSG00000204209
Uniprot IDs		Q99497 V9HWC2	A0A024RCS3 B4E1C1 Q53F85 Q9UER7
PDB IDs		1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36 4RKW 4RKY 4S0Z 4ZGG 5IP5 5SY6 5SY9 5SYA 6AF5 6AF7 6AF9 6AFA 6AFB 6AFC 6AFD 6AFE 6AFF 6AFG 6AFH 6AFI 6AFJ 6AFL 6E5Z 6M8Z 7C62	2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O
Enriched GO Terms of Interacting Partners?
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