DAXX and HSF1

Number of citations of the paper that reports this interaction (PubMedID 15016915)
35

Data Source:
BioGRID (pull down)
HPRD (in vivo, two hybrid)

		DAXX	HSF1
Description		death domain associated protein	heat shock transcription factor 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body PML Body	Kinetochore Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Perinuclear Region Of Cytoplasm Nuclear Stress Granule Mitotic Spindle Pole Chaperone Complex Ribonucleoprotein Complex
	Molecular Function	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein N-terminus Binding Androgen Receptor Binding Sumo-dependent Protein Binding Transcription Regulator Inhibitor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Heat Shock Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein Self-association Protein Heterodimerization Activity Hsp90 Protein Binding Translation Elongation Factor Binding STAT Family Protein Binding Sequence-specific Single Stranded DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Cellular Response To Heat Cellular Response To Unfolded Protein Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Positive Regulation Of Neuron Death Cellular Response To Sodium Arsenite	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade DNA Repair Regulation Of Transcription By RNA Polymerase II MRNA Processing Defense Response Response To Nutrient Positive Regulation Of Cell Population Proliferation MRNA Transcription Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Activity Negative Regulation Of Protein-containing Complex Assembly Response To Testosterone Cellular Response To Heat Cellular Response To Unfolded Protein Cellular Protein-containing Complex Assembly Cellular Response To Potassium Ion Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Estradiol Stimulus Cellular Response To Gamma Radiation Cellular Response To Diamide Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cellular Response To Heat Positive Regulation Of MRNA Polyadenylation Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic DNA Fragmentation Cellular Response To Sodium Arsenite Cellular Response To Angiotensin Positive Regulation Of Microtubule Binding Cellular Response To Nitroglycerin Cellular Response To L-glutamine Response To Hypobaric Hypoxia Response To Psychosocial Stress Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations	Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy
Drugs			Bimoclomol
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Dupuytren's disease ( 28886342)
Interacting Genes		123 interacting genes: ACVR2A ADGRF3 AIRE AMOTL2 AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CDSN CENPC CEP63 CEP70 CFLAR COL11A2 CREBBP CSNK2A1 DAPK3 DKC1 DMAP1 DNMT1 DXO ESRRG ETS1 FAM9B FANCA FAS FASLG FBXO25 FTH1 GAS8 GNL1 GOLGA2 GOLGA6L9 GRIPAP1 GTF2H4 H2BC15 H3-3B H3-5 H3C3 H4-16 H4C6 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 IKBKE KCTD4 MAP3K5 MCRS1 MDM2 MEN1 MIPOL1 MKRN1 MSANTD4 MX1 MYH11 NECAB2 NRG2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PIBF1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RASSF3 RIPK3 RNF4 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SQSTM1 SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TAX1BP1 TCF3 TCF4 TCF7L2 TFIP11 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TRIM54 TSG101 UBC UBE2I USH1G USP7 ZBTB2 ZBTB26	52 interacting genes: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 EEF1D ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA8 LY6E MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PIM2 PPID PRKDC PTGES3 RALBP1 REPS1 RNF20 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE
Entrez ID		1616	3297
HPRD ID		04424	00778
Ensembl ID		ENSG00000204209	ENSG00000185122
Uniprot IDs		A0A024RCS3 B4E1C1 Q53F85 Q9UER7	Q00613
PDB IDs		2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O	2LDU 5D5U 5D5V 5HDG 5HDN
Enriched GO Terms of Interacting Partners?
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