MAP4K1 and BLNK

Number of citations of the paper that reports this interaction (PubMedID 11514608)
17

Data Source:
HPRD (in vitro)

		MAP4K1	BLNK
Description		mitogen-activated protein kinase kinase kinase kinase 1	B cell linker
Image			No pdb structure
GO Annotations	Cellular Component	Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Enzyme Binding Protein Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Phospholipase Binding Protein Tyrosine Kinase Binding
	Biological Process	Protein Phosphorylation JNK Cascade Cell Population Proliferation Peptidyl-serine Phosphorylation Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Gene Expression B Cell Differentiation Intracellular Signal Transduction B Cell Receptor Signaling Pathway
Pathways			Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Fostamatinib
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101	25 interacting genes: AR BTK CBL CBLB CD72 CD79A CMTM3 CRKL EGFR ERBB2 ERBB3 GAB1 GRAP2 GRB2 ITK KIT LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		11184	29760
HPRD ID		03583	05153
Ensembl ID		ENSG00000104814	ENSG00000095585
Uniprot IDs		Q92918	Q2MD54 Q2MD59 Q8WV28
PDB IDs		6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0 7KAC
Enriched GO Terms of Interacting Partners?
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