TLK2 and DMAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TLK2	DMAP1
Description		tousled like kinase 2	DNA methyltransferase 1 associated protein 1
Image
GO Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Swr1 Complex Nucleus Nucleoplasm Replication Fork Cytoplasm Cytosol NuA4 Histone Acetyltransferase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity	Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair DNA Methylation Regulation Of Growth Positive Regulation Of Protein Import Into Nucleus Histone Exchange Histone H4 Acetylation Histone H2A Acetylation Response To Ethanol Negative Regulation Of Transcription, DNA-templated
Pathways			HATs acetylate histones
Drugs		Fostamatinib
Diseases
GWAS		Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: ASF1A ASF1B AURKA CEP70 DCAF7 DMAP1 DOCK1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ	39 interacting genes: ARFIP2 BFSP2 C1orf216 CCHCR1 CDCA7L DAXX DNMT1 EXOC8 GAS8 GINS4 HDAC2 HSF2BP HSPB1 ING1 KRT75 LMNB1 LRSAM1 MIS18A MNAT1 MORF4L1 MRGBP NAP1L2 OGT PFDN1 PIBF1 RGS6 SAAL1 SBK3 SUOX TCEANC TCHP TLK2 TOMM34 TRIM21 TSG101 TSGA10IP TXLNA TXLNB URI1
Entrez ID		11011	55929
HPRD ID		10527	05465
Ensembl ID		ENSG00000146872	ENSG00000178028
Uniprot IDs		B4DUC2 J3QLK5 Q86UE8	Q9NPF5
PDB IDs		5O0Y	3HM5 4IEJ
Enriched GO Terms of Interacting Partners?
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