TLK2 and DCAF7

		TLK2	DCAF7
Description		tousled like kinase 2	DDB1 and CUL4 associated factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Body Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	Protein Ubiquitination
Pathways			Association of TriC/CCT with target proteins during biosynthesis Neddylation
Drugs		Fostamatinib
Diseases
GWAS		Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: ASF1A ASF1B AURKA CEP70 DCAF7 DMAP1 DOCK1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ	17 interacting genes: ACE AIFM1 APP ATP13A2 ATP5PD BMPR1B CBX1 DYRK1B LIG1 PCTP PWP2 SPDYA TANC2 TK1 TLK2 YWHAB YWHAG
Entrez ID		11011	10238
HPRD ID		10527	09340
Ensembl ID		ENSG00000146872	ENSG00000136485
Uniprot IDs		B4DUC2 J3QLK5 Q86UE8	P61962
PDB IDs		5O0Y
Enriched GO Terms of Interacting Partners?
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