COPS5 and BRSK2

Number of citations of the paper that reports this interaction (PubMedID 22609399)
4

Data Source:
BioGRID (pull down, affinity chromatography technology)

		COPS5	BRSK2
Description		COP9 signalosome subunit 5	BR serine/threonine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Centrosome Perinuclear Region Of Cytoplasm Distal Axon
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Metalloendopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity NEDD8-specific Protease Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Isopeptidase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Tau Protein Binding Tau-protein Kinase Activity ATPase Binding ATPase Regulator Activity Protein Serine Kinase Activity
	Biological Process	Protein Deneddylation Translation Translational Initiation Protein Deubiquitination Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Axonogenesis Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Neuron Differentiation Actin Cytoskeleton Reorganization Intracellular Signal Transduction ERAD Pathway Cellular Response To Glucose Starvation Regulation Of ATPase Activity Regulation Of Axonogenesis Regulation Of Catalytic Activity Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Synaptic Vesicle Clustering
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Gout ( 32238385) Heroin dependence ( 27936112) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		99 interacting genes: APCS ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 CACNA1C CD274 CD93 CDKN1B CENPT COPS2 COPS3 COPS4 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 DDB1 DDO ERN1 ERRFI1 ESR1 F2RL1 GFER GFI1B GPS1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 IKBKB ITGB2 JUN JUND LASP1 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 VTN WNK1 YWHAG	7 interacting genes: CDC25B CDC25C COPS5 MAPT TRAF6 VCP WEE1
Entrez ID		10987	9024
HPRD ID		06888	11611
Ensembl ID		ENSG00000121022	ENSG00000174672
Uniprot IDs		A0A024R7W9 Q92905	A0A024RCE9 A0A140VJF6 B4DLY3 Q8IWQ3
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I
Enriched GO Terms of Interacting Partners?
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