COPS5 and PPOX

Number of citations of the paper that reports this interaction (PubMedID 18624398)
18

Data Source:
BioGRID (two hybrid)

		COPS5	PPOX
Description		COP9 signalosome subunit 5	protoporphyrinogen oxidase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Perinuclear Region Of Cytoplasm	Mitochondrial Intermembrane Space Intrinsic Component Of Mitochondrial Inner Membrane Integral Component Of Mitochondrial Inner Membrane Mitochondrial Membrane
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Metalloendopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity NEDD8-specific Protease Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Isopeptidase Activity	Oxygen-dependent Protoporphyrinogen Oxidase Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Protein Deneddylation Translation Translational Initiation Protein Deubiquitination Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion	Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Response To Xenobiotic Stimulus
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Heme biosynthesis
Drugs
Diseases
GWAS
Interacting Genes		99 interacting genes: APCS ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 CACNA1C CD274 CD93 CDKN1B CENPT COPS2 COPS3 COPS4 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 DDB1 DDO ERN1 ERRFI1 ESR1 F2RL1 GFER GFI1B GPS1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 IKBKB ITGB2 JUN JUND LASP1 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 VTN WNK1 YWHAG	4 interacting genes: COPS5 HAP1 HNRNPD IMMT
Entrez ID		10987	5498
HPRD ID		06888	02953
Ensembl ID		ENSG00000121022	ENSG00000143224
Uniprot IDs		A0A024R7W9 Q92905	P50336
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I	3NKS 4IVM 4IVO
Enriched GO Terms of Interacting Partners?
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