COPS8 and PDCD1

		COPS8	PDCD1
Description		COP9 signalosome subunit 8	programmed cell death 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Protein Deneddylation Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly	Adaptive Immune Response Apoptotic Process Humoral Immune Response Multicellular Organism Development Regulation Of Immune Response Negative Regulation Of Immune Response Positive Regulation Of T Cell Apoptotic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	PD-1 signaling Potential therapeutics for SARS
Drugs			CT-011 Nivolumab Pembrolizumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)	Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		19 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 DHFR EIF3E GPS1 ITPK1 MAPRE1 NFKBIA PDCD1 SUOX TP53 USHBP1	5 interacting genes: CD274 COPS8 MCL1 OR6B3 PDCD1LG2
Entrez ID		10920	5133
HPRD ID		16737	02590
Ensembl ID		ENSG00000198612	ENSG00000188389
Uniprot IDs		A0A024R4D1 Q99627	A0A0M3M0G7 Q15116
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CU5
Enriched GO Terms of Interacting Partners?
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