PPARGC1A and CAPNS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PPARGC1A	CAPNS1
Description		PPARG coactivator 1 alpha	calpain small subunit 1
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Mitochondrion PML Body Cytosolic Ribosome Neuronal Cell Body Intracellular Membrane-bounded Organelle Apical Dendrite	Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Peroxisome Proliferator Activated Receptor Binding Alpha-tubulin Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Response To Reactive Oxygen Species Autophagy Of Mitochondrion Temperature Homeostasis Cellular Glucose Homeostasis Negative Regulation Of Protein Phosphorylation Response To Dietary Excess Response To Ischemia Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Mitochondrion Organization Aging Digestion Androgen Metabolic Process RNA Splicing Response To Cold Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Skeletal Muscle Atrophy Response To Muscle Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Oxidation Cerebellum Development Respiratory Electron Transport Chain Forebrain Development Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Cellular Response To Potassium Ion Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Flavone Metabolic Process Adipose Tissue Development Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Nitrite Cellular Response To Caffeine Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Response To Norepinephrine Negative Regulation Of Mitochondrial Fission Energy Homeostasis Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Metformin Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process Cellular Response To Ionomycin Cellular Response To Resveratrol Response To Methionine Adaptive Thermogenesis Positive Regulation Of Progesterone Biosynthetic Process Negative Regulation Of Signaling Receptor Activity Regulation Of NMDA Receptor Activity Positive Regulation Of ATP Biosynthetic Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Heme signaling	Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			PD150606
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Essential tremor ( 27797806) Estimated glomerular filtration rate ( 31152163 31015462) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intralaminar thalamic nuclei volume ( 34006833) Lead levels ( 26025379) Molar-incisor hypomineralization ( 23918034) PR interval ( 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		44 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PCDH7 PPARA PPARD PPARG RARB RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2	20 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5
Entrez ID		10891	826
HPRD ID		05155	00240
Ensembl ID		ENSG00000109819	ENSG00000126247
Uniprot IDs		A0A024R9Q9 Q9UBK2	A0A0C4DGQ5 P04632
PDB IDs		1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6K0T 6KXX 6KXY 6LN4 6MS7 6NWK 6NWL 6W9K 6W9L	1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB
Enriched GO Terms of Interacting Partners?
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