PPARGC1A and CREBBP

Number of citations of the paper that reports this interaction (PubMedID 10558993)
211

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		PPARGC1A	CREBBP
Description		PPARG coactivator 1 alpha	CREB binding protein
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Mitochondrion PML Body Cytosolic Ribosome Neuronal Cell Body Intracellular Membrane-bounded Organelle Apical Dendrite	Histone Acetyltransferase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Peroxisome Proliferator Activated Receptor Binding Alpha-tubulin Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Transcription Coactivator Binding P53 Binding Chromatin Binding Damaged DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Chromatin DNA Binding Peptide N-acetyltransferase Activity MRF Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptide-lysine-N-acetyltransferase Activity
	Biological Process	Response To Reactive Oxygen Species Autophagy Of Mitochondrion Temperature Homeostasis Cellular Glucose Homeostasis Negative Regulation Of Protein Phosphorylation Response To Dietary Excess Response To Ischemia Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Mitochondrion Organization Aging Digestion Androgen Metabolic Process RNA Splicing Response To Cold Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Skeletal Muscle Atrophy Response To Muscle Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Oxidation Cerebellum Development Respiratory Electron Transport Chain Forebrain Development Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Cellular Response To Potassium Ion Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Flavone Metabolic Process Adipose Tissue Development Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Nitrite Cellular Response To Caffeine Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Response To Norepinephrine Negative Regulation Of Mitochondrial Fission Energy Homeostasis Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Metformin Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process Cellular Response To Ionomycin Cellular Response To Resveratrol Response To Methionine Adaptive Thermogenesis Positive Regulation Of Progesterone Biosynthetic Process Negative Regulation Of Signaling Receptor Activity Regulation Of NMDA Receptor Activity Positive Regulation Of ATP Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Acetylation Signal Transduction Regulation Of Smoothened Signaling Pathway Histone Acetylation N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Destabilization Cellular Response To UV Homeostatic Process Embryonic Digit Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein-containing Complex Assembly Regulation Of Cellular Response To Heat Histone Glutamine Methylation
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Heme signaling	Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation Cytoprotection by HMOX1 Heme signaling
Drugs			9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Essential tremor ( 27797806) Estimated glomerular filtration rate ( 31152163 31015462) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intralaminar thalamic nuclei volume ( 34006833) Lead levels ( 26025379) Molar-incisor hypomineralization ( 23918034) PR interval ( 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Neutrophil count ( 32888494) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Obesity-related traits ( 23251661) Pre-treatment viral load in HIV-1 infection ( 31219150) QT interval ( 24952745) QT interval (drug interaction) ( 23459443) White blood cell count ( 32888494)
Interacting Genes		44 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PCDH7 PPARA PPARD PPARG RARB RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2	358 interacting genes: ACSS1 ACTA2 ACTB ACVR1 AFP AIRE AKT1 ALX1 ANAPC5 ANAPC7 ANKS1A ANKS1B ANXA7 AP1B1 APC APP AR ATF1 ATF3 ATF4 ATF7IP ATRX BAG5 BCL3 BCL6 BRCA1 BRIP1 CALCOCO1 CAMK4 CAMSAP2 CARM1 CASP8AP2 CBX4 CDC25B CDH2 CDK5RAP3 CDX2 CEBPA CEBPB CEBPD CENPJ CEP290 CHAF1A CHD3 CHRDL1 CHUK CITED1 CITED2 CLASP2 CNOT3 CNTRL CPSF4 CREB1 CREM CRX CSK CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CUX1 DACH1 DAXX DDX17 DDX5 DEK DYRK1A E2F1 E2F3 E2F5 EBF1 EEF1A1 EEF2 EGR1 EID1 EID3 EIF2B1 EIF3D EIF4G2 ELF3 ELK1 EP300 EPG5 ESR1 ETS1 ETS2 EWSR1 EXOC5 FAF1 FBXL19 FBXO38 FGFR1 FHL2 FOS FOXM1 FOXO1 FOXO4 FUS GAA GABPA GAK GATA1 GATAD2A GCM1 GLI3 GMEB1 GMEB2 GPR161 GRIA3 GSTO2 GTF2B H2BC21 H2BC3 H3-3A H3-4 H3C1 H4-16 H4C1 HBP1 HCK HDAC1 HDAC3 HEXA HIF1A HIPK1 HIPK2 HIPK3 HIVEP1 HIVEP2 HLF HMG20A HMGA1 HMGB1 HMGB2 HMGXB4 HNF1A HNF1B HNF4A HNRNPL HOXA10 HOXA11 HOXA9 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD12 HOXD13 HOXD4 HSF1 HTT HUWE1 IKBKG IQGAP1 IRF1 IRF3 IRF5 IRF7 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KDM2A KDM2B KDM3B KDM6A KDM6B KHDRBS1 KIF5A KISS1 KLF1 KLF13 KLF4 KLF5 KMT2A KPNA2 KPNA6 LDLR LIG4 LYN MAF MAFG MAML1 MAML2 MAP1B MAP3K5 MAPK1 MAPK10 MAPK3 MAPT MBD2 MDC1 MDM2 MECOM MED25 MGMT MIER1 MKNK1 MSH2 MSH6 MSX1 MYB MYBL1 MYBL2 MYC MYO1E MYOD1 N4BP2 NAP1L1 NCOA1 NCOA2 NCOA3 NCOA6 NEUROG1 NFATC2 NFATC4 NFE2 NFE2L2 NFIA NFIC NKX2-1 NLK NPAS2 NPAT NR3C1 NR5A1 NUP98 OGT ONECUT1 PAPPA PARP1 PAX5 PAX6 PBX1 PCMT1 PCNA PELP1 PHLDA1 PHOX2A PIAS1 PIAS2 PIAS3 PLAGL1 PML POLR2A POU1F1 POU2F3 PPARG PPARGC1A PPP1R8 PPP2R2A PRKCD PRLR PROX1 PSME3 PTMA PTPRF RAD23A RAD50 RBBP4 RBBP7 RBCK1 RBM24 RBM5 RELA RFK RNF111 RNF7 RPL3 RPL35 RPS20 RPS6KA1 RPS6KA3 RPS6KA5 RXRG SEMA3B SEPTIN3 SERTAD1 SERTAD2 SERTAD3 SETDB1 SH3GL1 SLC1A4 SMAD2 SMAD3 SMAD4 SNAPC5 SND1 SNIP1 SNRNP200 SOS2 SOX9 SP100 SPI1 SPIB SPTAN1 SRCAP SREBF1 SREBF2 SRF SS18L1 STAT1 STAT2 STAT3 STAT4 STAT6 SUMO1 SUV39H1 SYT1 TACC2 TAF6L TCF12 TCF3 TDG TFDP1 TGS1 THRA TIAL1 TIAM1 TOPORS TP53 TP53BP2 TP73 TRERF1 TRIM24 TRIP10 TRIP4 TSPYL2 TUBB UBE2D1 UBE2I UBTF UIMC1 VAT1L VDR WAS WDR77 WT1 XAF1 XRCC6 YTHDF2 YWHAH ZBTB17 ZBTB2 ZCCHC7 ZHX1 ZMYM2 ZMYM5 ZNF106 ZNF451 ZNF639 ZNFX1
Entrez ID		10891	1387
HPRD ID		05155	02534
Ensembl ID		ENSG00000109819	ENSG00000005339
Uniprot IDs		A0A024R9Q9 Q9UBK2	Q92793
PDB IDs		1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6K0T 6KXX 6KXY 6LN4 6MS7 6NWK 6NWL 6W9K 6W9L	1JSP 1LIQ 1RDT 1WO3 1WO4 1WO5 1WO6 1WO7 1ZOQ 2D82 2KJE 2KWF 2L84 2L85 2LXS 2LXT 2N1A 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF 4TQN 4TS8 4WHU 4YK0 5CGP 5DBM 5EIC 5ENG 5EP7 5GH9 5H85 5I83 5I86 5I89 5I8B 5I8G 5J0D 5JEM 5KTU 5KTW 5KTX 5LPJ 5LPL 5MME 5MMG 5MPK 5MPN 5MPZ 5MQE 5MQG 5MQK 5NLK 5NRW 5NU3 5OWK 5SVH 5TB6 5W0E 5W0F 5W0L 5W0Q 5XXH 6ALB 6ALC 6AXQ 6AY3 6AY5 6DMK 6ES5 6ES6 6ES7 6FQO 6FQT 6FQU 6FR0 6FRF 6QST 6SQE 6SQF 6SQM 6SXX 6YIJ 6YIK 6YIL 6YIM 7CO1 7JFL 7JFM
Enriched GO Terms of Interacting Partners?
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