USP20 and CLSPN

Number of citations of the paper that reports this interaction (PubMedID 25326330)
23

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		USP20	CLSPN
Description		ubiquitin specific peptidase 20	claspin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Zinc Ion Binding	DNA Secondary Structure Binding Protein Binding Anaphase-promoting Complex Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling
Pathways		Ub-specific processing proteases	Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		69 interacting genes: AGR2 ALAS1 APBA2 ARID5A ASCL1 ATP6V1G2 BEND5 BEND7 BHLHB9 BRPF1 C1QTNF2 CCNL2 CDK2AP1 CLSPN CTAG1A CTAG1B DIO2 ENKD1 EPAS1 FATE1 FTO GPRASP2 GTF2IRD1 HAND2 HIF1A HSF2BP IHO1 IRAK1BP1 ITGB3BP KLHL20 LMNA MAGEA11 MAPK6 MBD3L1 MCCD1 MDFI MEOX2 MRPL28 PBX4 PJA1 PLA2G2A PRKACA PRKCI RAD17 RSPO4 SAMD12 SPRY2 SRGAP2B STING1 TNNI1 TRIB3 TRIM23 TTC19 TTC23L ULK1 USP15 USP21 USP28 VAPA VAPB VAX1 VHL WASHC1 ZBTB10 ZFYVE26 ZNF343 ZNF408 ZNF620 ZXDB	12 interacting genes: ATR BRCA1 C1orf50 CASP7 CDC7 CHEK1 FZR1 RAD9A USP20 USP28 USP29 USP7
Entrez ID		10868	63967
HPRD ID		07505	09257
Ensembl ID		ENSG00000136878	ENSG00000092853
Uniprot IDs		Q9Y2K6	Q9HAW4
PDB IDs		6KCZ
Enriched GO Terms of Interacting Partners?
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