CLSPN and USP28

Number of citations of the paper that reports this interaction (PubMedID 16901786)
146

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CLSPN	USP28
Description		claspin	ubiquitin specific peptidase 28
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	DNA Secondary Structure Binding Protein Binding Anaphase-promoting Complex Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling	DNA Damage Checkpoint Signaling DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends	Ub-specific processing proteases
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		12 interacting genes: ATR BRCA1 C1orf50 CASP7 CDC7 CHEK1 FZR1 RAD9A USP20 USP28 USP29 USP7	40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		63967	57646
HPRD ID		09257	15632
Ensembl ID		ENSG00000092853	ENSG00000048028
Uniprot IDs		Q9HAW4	B4E3L3 Q96RU2
PDB IDs			2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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