ZNF274 and NGFR

Number of citations of the paper that reports this interaction (PubMedID 10545116)
37

Data Source:
HPRD (in vitro, in vivo)

		ZNF274	NGFR
Description		zinc finger protein 274	nerve growth factor receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Integral Component Of Membrane Growth Cone Dendritic Spine Perikaryon
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K9 Trimethylation	Cellular Glucose Homeostasis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Rho Protein Signal Transduction Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Fibroblast Proliferation Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Generic Transcription Pathway	Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs
Diseases
GWAS		Cholesterol, total ( 25961943) LDL cholesterol ( 25961943) Ovarian cancer ( 30557369)	Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		1 interacting genes: NGFR	51 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A COL6A3 EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274
Entrez ID		10782	4804
HPRD ID		05682	01197
Ensembl ID		ENSG00000171606	ENSG00000064300
Uniprot IDs		A0A0A0MR47 Q96GC6	P08138
PDB IDs			2N80 2N83 2N97 3EWV 5ZGG
Enriched GO Terms of Interacting Partners?
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