NUP50 and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NUP50	KPNA4
Description		nucleoporin 50	karyopherin subunit alpha 4
Image
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Nuclear Membrane	Nucleus Nucleoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Protein Import Into Nucleus MRNA Transport	NLS-bearing Protein Import Into Nucleus
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		14 interacting genes: APP CDKN1B IPO13 KEAP1 KPNA1 KPNA2 KPNA4 KPNA5 KPNA6 KPNB1 OGT RAN SRPK2 XPO1	27 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 FAM50B GTF2IRD1 HIF1A HNRNPC HSD3B7 KAT5 KPNB1 MAT2B MTA1 NCBP3 NFE2L2 NTRK3 NUP50 OGT PLAA RAC1 RCC1 RECQL TGM2 WT1
Entrez ID		10762	3840
HPRD ID		05226	04275
Ensembl ID		ENSG00000093000	ENSG00000186432
Uniprot IDs		A0A024R4X7 B4E2D3 Q9UKX7	O00629
PDB IDs		2EC1 3TJ3	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL
Enriched GO Terms of Interacting Partners?
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