IGF2BP2 and CD47

		IGF2BP2	CD47
Description		insulin like growth factor 2 mRNA binding protein 2	CD47 molecule
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Translation Regulator Activity MRNA 5'-UTR Binding	Protein Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity
	Biological Process	Regulation Of Cytokine Production Nervous System Development Anatomical Structure Morphogenesis Regulation Of Gene Expression Negative Regulation Of Translation MRNA Transport Regulation Of RNA Metabolic Process	Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Regulation Of Interferon-gamma Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Positive Regulation Of Stress Fiber Assembly Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 ATP Export Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Monocyte Extravasation
Pathways		Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Acute insulin response ( 28490609) Blood sugar levels ( 29403010) Body mass index ( 29381148 28892062) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Childhood onset type 2 diabetes ( 33479058) Coronary artery disease ( 29212778) Diabetes (gestational) ( 22233651) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) FEV1 ( 30804560) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 31562340) Hemoglobin A1c levels ( 29403010) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Lymphocyte counts ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Peak insulin response ( 28490609) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Thyroid stimulating hormone levels ( 30367059 32769997) Triglyceride levels ( 32203549) Two-hour glucose ( 34059833) Type 2 diabetes ( 21573907 27189021 22885922 18372903 24509480 30054458 18711366 26961502 29358691 30297969 29632382 23945395 31118516 25760438 23300278 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 33263727 31043756) Body mass index ( 25673413) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		74 interacting genes: CD47 HNRNPD MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT	24 interacting genes: BNIP3 EPB42 FAS GAP43 GNAI1 IGF2BP2 IGSF8 ITGAV MAP3K10 MTIF3 MUC1 P2RY2 PLA1A PTK2 PVR RHAG SIRPA SYNE4 TAGLN3 TFEB THBS1 TMEM167B UBQLN1 ZBTB20
Entrez ID		10644	961
HPRD ID		10507	03017
Ensembl ID		ENSG00000073792	ENSG00000196776
Uniprot IDs		B3FTN5 B4DKT5 F8W930 Q9Y6M1	A0A0A1TSG4 Q08722
PDB IDs		2CQH 6ROL	2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU
Enriched GO Terms of Interacting Partners?
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