IGF2BP2 and MIR16-2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
92

Data Source:
BioGRID (unspecified method)

		IGF2BP2	MIR16-2
Description		insulin like growth factor 2 mRNA binding protein 2	microRNA 16-2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton	Extracellular Space
	Molecular Function	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Translation Regulator Activity MRNA 5'-UTR Binding
	Biological Process	Regulation Of Cytokine Production Nervous System Development Anatomical Structure Morphogenesis Regulation Of Gene Expression Negative Regulation Of Translation MRNA Transport Regulation Of RNA Metabolic Process	Gene Silencing By MiRNA
Pathways		Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Drugs
Diseases
GWAS		Acute insulin response ( 28490609) Blood sugar levels ( 29403010) Body mass index ( 29381148 28892062) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Childhood onset type 2 diabetes ( 33479058) Coronary artery disease ( 29212778) Diabetes (gestational) ( 22233651) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) FEV1 ( 30804560) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 31562340) Hemoglobin A1c levels ( 29403010) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Lymphocyte counts ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Peak insulin response ( 28490609) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Thyroid stimulating hormone levels ( 30367059 32769997) Triglyceride levels ( 32203549) Two-hour glucose ( 34059833) Type 2 diabetes ( 21573907 27189021 22885922 18372903 24509480 30054458 18711366 26961502 29358691 30297969 29632382 23945395 31118516 25760438 23300278 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 31043756) Malaria ( 31844061)
Interacting Genes		74 interacting genes: CD47 HNRNPD MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT	83 interacting genes: ADARB1 APOBEC3B ATXN2L C1QBP CPSF1 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI2 NOL6 NONO NUDT21 PDCD11 PRMT1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RBMS1 RBMS2 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM25 UPF1 UTP20 YBX1 YBX2 YBX3 ZC3H7A ZC3H7B ZFR ZNF346
Entrez ID		10644	406951
HPRD ID		10507
Ensembl ID		ENSG00000073792	ENSG00000198987
Uniprot IDs		B3FTN5 B4DKT5 F8W930 Q9Y6M1
PDB IDs		2CQH 6ROL
Enriched GO Terms of Interacting Partners?
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