CENPE and DNAJB1

Number of citations of the paper that reports this interaction (PubMedID 19779646)
3

Data Source:
BioGRID (two hybrid)

		CENPE	DNAJB1
Description		centromere protein E	DnaJ heat shock protein family (Hsp40) member B1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Kinetochore Microtubule Cytosol Microtubule Microtubule Cytoskeleton Membrane Midbody Spindle Midzone Mitotic Spindle Midzone	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Kinetochore Binding	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding
	Biological Process	Mitotic Cell Cycle Microtubule-based Movement Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore	Negative Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
Drugs		GSK-923295
Diseases
GWAS		Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 25877299 28604728 28604732 23666240)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		13 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 DUX1 FANCA NUF2 RHEB SEPTIN7 SKP1 TRAF4 UBC	31 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CENPE CYP2C8 DNAJC3 DNM2 ECSIT FANCA FANCC GLB1 GSK3A HSF1 HSPA1A MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TTLL12 ZFP36
Entrez ID		1062	3337
HPRD ID		00316	05198
Ensembl ID		ENSG00000138778	ENSG00000132002
Uniprot IDs		Q02224	P25685 Q6FHS4
PDB IDs		1T5C 5JVP	1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR 6WJF 6WJG 6Z5N
Enriched GO Terms of Interacting Partners?
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