PAICS and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PAICS	PIAS2
Description		phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding 5-amino-4-imidazole Carboxylate Lyase Activity Cadherin Binding	DNA Binding Transcription Coregulator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Purine ribonucleoside monophosphate biosynthesis	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Aspartic acid
Diseases
GWAS			Fruit consumption ( 32066663)
Interacting Genes		21 interacting genes: CDC37 CEP76 CHD3 FXR1 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PIAS2 PILRA PRKAG1 PTPRC RAD54L2 RNF4 SMARCD1 TERF1 UBE2I UBE3A ZMYM2	126 interacting genes: - ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TCF4 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2
Entrez ID		10606	9063
HPRD ID		01401	06944
Ensembl ID		ENSG00000128050	ENSG00000078043
Uniprot IDs		P22234	A0A024RC49 O75928 Q2TA77
PDB IDs		2H31 6YB8 6YB9	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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