UMPS and A2M

Number of citations of the paper that reports this interaction (PubMedID 21163940)
36

Data Source:
BioGRID (two hybrid)

		UMPS	A2M
Description		uridine monophosphate synthetase	alpha-2-macroglobulin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Orotate Phosphoribosyltransferase Activity Orotidine-5'-phosphate Decarboxylase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	'de Novo' Pyrimidine Nucleobase Biosynthetic Process UMP Biosynthetic Process Female Pregnancy Lactation Nucleoside Metabolic Process Pyrimidine Nucleobase Biosynthetic Process 'de Novo' UMP Biosynthetic Process Cellular Response To Xenobiotic Stimulus	Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Endopeptidase Activity Stem Cell Differentiation
Pathways		Pyrimidine biosynthesis	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs		6-hydroxyuridine-5'-phosphate	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Plateletcrit ( 32888494) Serum metabolite levels ( 33031748)	Refractive error ( 32231278)
Interacting Genes		16 interacting genes: A2M CALU CASP8 CDC42EP3 DLST NOS3 OGT PAXIP1 PIK3CA PLA2G12A PSEN1 RAD51 RB1CC1 RPS29 SUMO2 ZNF227	98 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS
Entrez ID		7372	2
HPRD ID		02022	00072
Ensembl ID		ENSG00000114491	ENSG00000175899
Uniprot IDs		A8K5J1 P11172	P01023
PDB IDs		2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?
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