MERTK and TNK2

Number of citations of the paper that reports this interaction (PubMedID 16288044)
99

Data Source:
HPRD (in vivo)

		MERTK	TNK2
Description		MER proto-oncogene, tyrosine kinase	tyrosine kinase non receptor 2
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Rhabdomere Receptor Complex	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Grb2-EGFR Complex Cytoophidium
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity
	Biological Process	Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Spermatogenesis Nervous System Development Cell Migration Peptidyl-tyrosine Phosphorylation Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Protein Kinase B Signaling Positive Regulation Of Phagocytosis Negative Regulation Of Lymphocyte Activation Retina Development In Camera-type Eye Vagina Development Neutrophil Clearance Negative Regulation Of Leukocyte Apoptotic Process	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Differentiation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis
Pathways		Cell surface interactions at the vascular wall
Drugs		2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol Fostamatinib	ATP Debromohymenialdisine Entrectinib Fostamatinib
Diseases
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Coronary artery disease ( 29212778 33020668) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 31604244 21833088) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure ( 30224653)	Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)
Interacting Genes		9 interacting genes: BMPR2 ERBB2 GAS6 GRB2 IKBKG LMO4 NEDD4L TNK2 VAV1	49 interacting genes: AKT1 AQP1 AR ARSL BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1
Entrez ID		10461	10188
HPRD ID		05269	06104
Ensembl ID		ENSG00000153208	ENSG00000061938
Uniprot IDs		Q12866	A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 B3KXJ4 C9J1X3 Q07912
PDB IDs		2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA 5K0K 5K0X 5TC0 5TD2 5U6C 6MEP 7AAX 7AAY 7AAZ 7AB0 7AB1 7AB2 7AVX 7AVY 7AVZ 7AW0 7AW1 7AW2 7AW3 7AW4 7CQE	1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB 6VQM
Enriched GO Terms of Interacting Partners?
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