MERTK

Description		MER proto-oncogene, tyrosine kinase
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Rhabdomere Receptor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Spermatogenesis Nervous System Development Cell Migration Peptidyl-tyrosine Phosphorylation Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Protein Kinase B Signaling Positive Regulation Of Phagocytosis Negative Regulation Of Lymphocyte Activation Retina Development In Camera-type Eye Vagina Development Neutrophil Clearance Negative Regulation Of Leukocyte Apoptotic Process
Pathways		Cell surface interactions at the vascular wall
Drugs		2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol Fostamatinib
Diseases
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Coronary artery disease ( 29212778 33020668) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 31604244 21833088) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		9 interacting genes: BMPR2 ERBB2 GAS6 GRB2 IKBKG LMO4 NEDD4L TNK2 VAV1
Entrez ID		10461
HPRD ID		05269
Ensembl ID		ENSG00000153208
Uniprot IDs		Q12866
PDB IDs		2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA 5K0K 5K0X 5TC0 5TD2 5U6C 6MEP 7AAX 7AAY 7AAZ 7AB0 7AB1 7AB2 7AVX 7AVY 7AVZ 7AW0 7AW1 7AW2 7AW3 7AW4 7CQE
Enriched GO Terms of Interacting Partners?
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