IFITM3 and SGPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IFITM3	SGPL1
Description		interferon induced transmembrane protein 3	sphingosine-1-phosphate lyase 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Protein Binding Sphinganine-1-phosphate Aldolase Activity Pyridoxal Phosphate Binding
	Biological Process	Immune Response Response To Virus Negative Regulation Of Viral Transcription Response To Interferon-gamma Response To Interferon-alpha Response To Interferon-beta Negative Regulation Of Viral Genome Replication Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway	Luteinization Vasculogenesis Kidney Development Fatty Acid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway
Pathways		Interferon alpha/beta signaling	Sphingolipid de novo biosynthesis
Drugs			Pyridoxal phosphate
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		27 interacting genes: ABHD16A AQP6 CD53 ELOVL2 ERGIC3 FAM210B FFAR2 FKBP7 GLP1R GPR37 GPRC5D KIR2DL3 LYPD5 MS4A3 NEDD4 OPRM1 PLP1 PTAFR REEP4 RETREG3 SGPL1 SLC10A1 SLC10A2 SLC16A7 TMEM14B TMEM86B VKORC1	37 interacting genes: ANK3 AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 DDX21 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TRARG1 TSPAN4 UNC50
Entrez ID		10410	8879
HPRD ID		05719	07224
Ensembl ID		ENSG00000142089	ENSG00000166224
Uniprot IDs		Q01628	O95470
PDB IDs			4Q6R
Enriched GO Terms of Interacting Partners?
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