SGPL1 and UNC50

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SGPL1	UNC50
Description		sphingosine-1-phosphate lyase 1	unc-50 inner nuclear membrane RNA binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nuclear Inner Membrane Integral Component Of Golgi Membrane
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Pyridoxal Phosphate Binding	RNA Binding Protein Binding
	Biological Process	Luteinization Vasculogenesis Kidney Development Fatty Acid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Protein Transport Protein Localization To Cell Surface
Pathways		Sphingolipid de novo biosynthesis
Drugs		Pyridoxal phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Diverticular disease ( 30177863)
Interacting Genes		37 interacting genes: ANK3 AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 DDX21 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TRARG1 TSPAN4 UNC50	33 interacting genes: AQP6 CLEC10A CLRN1 CREB3 DARS2 EBP ELOVL4 ERGIC3 FAM209A FCER1G FFAR2 FITM2 GPR152 GPX8 HSD17B11 HSD17B13 IFNGR2 KCNJ6 LMNA MFF MFSD14B MGST3 MTIF3 MUC1 REEP4 SAR1A SGPL1 SLC10A1 SLC10A6 TMED8 TMEM14B TMEM167B TMEM234
Entrez ID		8879	25972
HPRD ID		07224	18259
Ensembl ID		ENSG00000166224	ENSG00000115446
Uniprot IDs		O95470	A0A0S2Z612 J3KQ47 Q53HI1
PDB IDs		4Q6R
Enriched GO Terms of Interacting Partners?
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