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IRAG1 and ITPR1
Number of citations of the paper that reports this interaction (PubMedID
10724174
)
111
Data Source:
HPRD
(in vivo)
IRAG1
ITPR1
Description
inositol 1,4,5-triphosphate receptor associated 1
inositol 1,4,5-trisphosphate receptor type 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Sarcoplasmic Reticulum
Platelet Dense Tubular Network Membrane
Perinuclear Region Of Cytoplasm
Nuclear Inner Membrane
Nucleolus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Calcineurin Complex
Postsynaptic Density
Membrane
Integral Component Of Membrane
Sarcoplasmic Reticulum
Transport Vesicle Membrane
Cytoplasmic Vesicle Membrane
Secretory Granule Membrane
Platelet Dense Granule Membrane
Platelet Dense Tubular Network
Platelet Dense Tubular Network Membrane
Perinuclear Region Of Cytoplasm
Schaffer Collateral - CA1 Synapse
Molecular Function
Protein Binding
Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Calcium Ion Binding
Protein Binding
Calcium Ion Transmembrane Transporter Activity
Calcium-release Channel Activity
Calcium Channel Inhibitor Activity
Phosphatidylinositol Binding
Inositol 1,4,5 Trisphosphate Binding
Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels
Biological Process
CGMP-mediated Signaling
Response To Hypoxia
Calcium Ion Transport
Signal Transduction
Post-embryonic Development
Regulation Of Autophagy
Endoplasmic Reticulum Calcium Ion Homeostasis
Epithelial Fluid Transport
Inositol Phosphate-mediated Signaling
Negative Regulation Of Calcium-mediated Signaling
Voluntary Musculoskeletal Movement
Release Of Sequestered Calcium Ion Into Cytosol
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways
cGMP effects
PLC beta mediated events
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
DAG and IP3 signaling
Role of phospholipids in phagocytosis
FCERI mediated Ca+2 mobilization
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Ca2+ pathway
cGMP effects
Regulation of insulin secretion
VEGFR2 mediated cell proliferation
Ion homeostasis
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
FCGR3A-mediated IL10 synthesis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Caffeine
1D-myo-inositol 1,4,5-trisphosphate
Glycerin
Diseases
GWAS
Airflow obstruction (
22837378
)
Breast cancer (
23535729
)
Calcium levels (
29403010
)
Diabetic kidney disease (
26305897
)
Gamma glutamyl transferase levels (
29403010
33339817
)
Hand grip strength (
29691431
)
HDL cholesterol levels in HIV infection (
33109212
)
Hematocrit (
32888494
)
Lead levels (
26025379
)
Metabolite levels (
23823483
)
Multiple sclerosis (
31604244
)
Obesity-related traits (
23251661
)
Systolic blood pressure (
26969751
)
Thrombin-activatable fibrinolysis inhibitor activation peptide (
29378355
)
Triglyceride levels (
32203549
32154731
)
Uterine fibroids (
30194396
)
Weight (
28552196
)
Western dietary pattern (
28644415
)
Interacting Genes
3 interacting genes:
ASXL1
ITPR1
PRKG1
32 interacting genes:
AHCYL1
AKT1
ARHGAP1
BANK1
BCL2
BECN1
BRCA1
CA8
CABP1
CCNB1
CDK1
EPB41L1
ERBB2
ERP44
FKBP1A
FYN
GRM1
HOMER1
HOMER2
HOMER3
IRAG1
ITPR3
ITPRIP
LYN
PRKACA
PRKCD
PRKG1
RHOA
RYR2
STARD13
TRPC3
TRPC4
Entrez ID
10335
3708
HPRD ID
05242
00925
Ensembl ID
ENSG00000072952
ENSG00000150995
Uniprot IDs
Q9Y6F6
A0A3B3ITU8
A0A3F2YNW8
B4DER3
B4DGH1
Q14643
Q59H91
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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