ITPR1 and BANK1

Number of citations of the paper that reports this interaction (PubMedID 11782428)
68

Data Source:
HPRD (in vivo)

		ITPR1	BANK1
Description		inositol 1,4,5-trisphosphate receptor type 1	B cell scaffold protein with ankyrin repeats 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse	Perinuclear Region Of Cytoplasm
	Molecular Function	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium-release Channel Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels	Protease Binding NAD+ Nucleosidase Activity Signaling Receptor Binding Protein Binding Signaling Adaptor Activity Phospholipase Binding Protein Tyrosine Kinase Binding
	Biological Process	Response To Hypoxia Calcium Ion Transport Signal Transduction Post-embryonic Development Regulation Of Autophagy Endoplasmic Reticulum Calcium Ion Homeostasis Epithelial Fluid Transport Inositol Phosphate-mediated Signaling Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Response To Bacterium Negative Regulation Of Interleukin-6 Production B Cell Activation Positive Regulation Of MAPK Cascade Negative Regulation Of Translational Initiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Negative Regulation Of Protein Kinase B Signaling
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases
GWAS		Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Gamma glutamyl transferase levels ( 29403010 33339817) Hand grip strength ( 29691431) HDL cholesterol levels in HIV infection ( 33109212) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32203549 32154731) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)	Adventurousness ( 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 33654092) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 22763476) Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 28165464 26956414) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 30224653) General cognitive ability ( 29844566) ghrelin levels ( 33852427) Gut microbiota (beta diversity) ( 27723756) Hand grip strength ( 29691431) Hypertension ( 31879980) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lupus nephritis in systemic lupus erythematosus ( 34127828) Mean platelet volume ( 32888494 27863252) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Schizophrenia ( 29483656) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 27399966 18204447 23273568 33272962 26502338 28714469) Systolic blood pressure ( 30578418)
Interacting Genes		32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4	4 interacting genes: ITPR1 ITPR2 LYN TRAF6
Entrez ID		3708	55024
HPRD ID		00925	09819
Ensembl ID		ENSG00000150995	ENSG00000153064
Uniprot IDs		A0A3B3ITU8 A0A3F2YNW8 B4DER3 B4DGH1 Q14643 Q59H91	Q8NDB2
PDB IDs
Enriched GO Terms of Interacting Partners?
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