AKR1A1 and TERF2IP

Number of citations of the paper that reports this interaction (PubMedID 21044950)
51

Data Source:
BioGRID (two hybrid)

		AKR1A1	TERF2IP
Description		aldo-keto reductase family 1 member A1	TERF2 interacting protein
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol Apical Plasma Membrane Synapse Extracellular Exosome	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Shelterin Complex
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity NAD-retinol Dehydrogenase Activity Protein Binding Electron Transfer Activity Allyl-alcohol Dehydrogenase Activity D-threo-aldose 1-dehydrogenase Activity L-glucuronate Reductase Activity Glucuronolactone Reductase Activity Glycerol Dehydrogenase [NADP+] Activity Methylglyoxal Reductase (NADPH-dependent, Acetol Producing)	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Glucose Metabolic Process Cellular Aldehyde Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate L-ascorbic Acid Biosynthetic Process Electron Transport Chain D-glucuronate Catabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Glutathione Derivative Biosynthetic Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Acetylation
Pathways		Glutathione conjugation Formation of xylulose-5-phosphate	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		Tolrestat Nicotinamide adenine dinucleotide phosphate Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 32888494 27863252) Pulse pressure ( 30224653 30578418) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Weight ( 34074324)
Interacting Genes		4 interacting genes: EXOSC4 HTR6 TERF1 TERF2IP	121 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 GAGE5 GAMT GNMT GPAA1 H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414
Entrez ID		10327	54386
HPRD ID		00069	05452
Ensembl ID		ENSG00000117448	ENSG00000166848
Uniprot IDs		P14550 V9HWI0	Q9NYB0
PDB IDs		2ALR	1FEX 3K6G 4RQI
Enriched GO Terms of Interacting Partners?
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