AKR1A1

Description		aldo-keto reductase family 1 member A1
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol Apical Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity NAD-retinol Dehydrogenase Activity Protein Binding Electron Transfer Activity Allyl-alcohol Dehydrogenase Activity D-threo-aldose 1-dehydrogenase Activity L-glucuronate Reductase Activity Glucuronolactone Reductase Activity Glycerol Dehydrogenase [NADP+] Activity Methylglyoxal Reductase (NADPH-dependent, Acetol Producing)
	Biological Process	Glucose Metabolic Process Cellular Aldehyde Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate L-ascorbic Acid Biosynthetic Process Electron Transport Chain D-glucuronate Catabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Glutathione Derivative Biosynthetic Process
Pathways		Glutathione conjugation Formation of xylulose-5-phosphate
Drugs		Tolrestat Nicotinamide adenine dinucleotide phosphate Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 32888494 27863252) Pulse pressure ( 30224653 30578418) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: EXOSC4 HTR6 TERF1 TERF2IP
Entrez ID		10327
HPRD ID		00069
Ensembl ID		ENSG00000117448
Uniprot IDs		P14550 V9HWI0
PDB IDs		2ALR
Enriched GO Terms of Interacting Partners?
Tagcloud ?