CDKN1C and FBXL12

Number of citations of the paper that reports this interaction (PubMedID 18660753)
21

Data Source:
HPRD (in vivo)

		CDKN1C	FBXL12
Description		cyclin dependent kinase inhibitor 1C	F-box and leucine rich repeat protein 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Cell Cycle Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Kinase Activity	G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Cycle
Pathways		Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Calcium levels ( 20705733) Malaria ( 31844061) Type 1 diabetes ( 34012112)	Pursuit maintenance gain ( 29064472)
Interacting Genes		11 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2 SLC2A1	24 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FBF1 FXYD3 GEMIN4 LNX1 MARCHF2 MAST1 PSEN1 PSEN2 PSME3 RNF32 SHFL SMAD1 TGFBR1 UBE2D3 ZNF44 ZNF562 ZNF823
Entrez ID		1028	54850
HPRD ID		02913	12363
Ensembl ID		ENSG00000129757	ENSG00000127452
Uniprot IDs		P49918	Q9NXK8
PDB IDs
Enriched GO Terms of Interacting Partners?
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