CDKN1C and NR4A2

Number of citations of the paper that reports this interaction (PubMedID 14671317)
47

Data Source:
HPRD (in vitro)

		CDKN1C	NR4A2
Description		cyclin dependent kinase inhibitor 1C	nuclear receptor subfamily 4 group A member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Protein-containing Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Glucocorticoid Receptor Binding Retinoid X Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Cycle Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Kinase Activity	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Neuron Migration Response To Amphetamine Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Signal Transduction Adult Locomotory Behavior Post-embryonic Development Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Differentiation Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Neuron Maturation Positive Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II General Adaptation Syndrome Canonical Wnt Signaling Pathway Cellular Response To Corticotropin-releasing Hormone Stimulus Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs
Diseases
GWAS		Birth weight ( 31043758) Calcium levels ( 20705733) Malaria ( 31844061) Type 1 diabetes ( 34012112)	Age at voice drop ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Chronic obstructive pulmonary disease ( 30804561) Depression ( 29700475) HDL cholesterol levels ( 32109663) Leisure-time exercise behaviour ( 30102679) Leisure-time exercise behaviour (age-stratified) ( 30102679) Lung function (FEV1/FVC) ( 30061609) Menarche (age at onset) ( 21102462 25231870) Response to statin therapy ( 20339536) Schizophrenia ( 33169155) Sociability score ( 34054130) Worry too long after an embarrassing experience ( 34054130)
Interacting Genes		11 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2 SLC2A1	18 interacting genes: BAZ1B CDKN1C CDKN2D CHST13 COPS5 FAP MAPK1 ODAD2 PIAS4 PPARG RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 SMPD4 TCEAL5 VHL
Entrez ID		1028	4929
HPRD ID		02913	03493
Ensembl ID		ENSG00000129757	ENSG00000153234
Uniprot IDs		P49918	F1D8N6 F1DAL2 P43354 Q53EL4
PDB IDs			1OVL 5Y41 5YD6 6DDA 6L6L 6L6Q
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?