SPRY3 and R3HDM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPRY3	R3HDM2
Description		sprouty RTK signaling antagonist 3	R3H domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Nucleus
	Molecular Function	Molecular_function Protein Binding	RNA Binding Protein Binding
	Biological Process	Multicellular Organism Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Axon Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Projection Arborization
Pathways
Drugs
Diseases
GWAS		Idiopathic osteonecrosis of the femoral head ( 28000841) Iron status biomarkers (transferrin saturation) ( 28334935)	Apolipoprotein B levels ( 32203549) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163 31015462) Glomerular filtration rate (creatinine) ( 28452372) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Monocyte count ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32203549 32154731) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 20884846 31578528) Urate levels in overweight individuals ( 25811787)
Interacting Genes		27 interacting genes: AQP1 BEX2 CATSPER1 CHRD CREB5 GNE GPSM3 HOXA1 HR KPRP KRT34 LCE1A LCE1B LCE1F LCE2B LCE3A LCE3D LCE3E MAPKBP1 MEOX2 NEK6 R3HDM2 SLC39A7 VSNL1 ZDHHC17 ZNF587 ZNF655	26 interacting genes: ADAMTSL4 ATXN1 C1orf94 CYSRT1 FAM168A INCA1 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-3 KRTAP3-2 KRTAP4-12 MEI4 MGAT5B NBPF19 NOTCH2NLA RBPMS REL SPRY1 SPRY3 TRIM42
Entrez ID		10251	22864
HPRD ID		03917	13827
Ensembl ID		ENSG00000168939	ENSG00000179912
Uniprot IDs		O43610 Q6ZUP3	A0A0U1RRA6 B5MCG9 Q9Y2K5
PDB IDs			1WHR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?