CDK6 and ELK1

Number of citations of the paper that reports this interaction (PubMedID 22094256)
217

Data Source:
BioGRID (enzymatic study)

		CDK6	ELK1
Description		cyclin dependent kinase 6	ETS transcription factor ELK1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Ruffle Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Mediator Complex	Chromatin Nucleus Nucleoplasm Mitochondrion Dendrite Neuronal Cell Body Axon Terminus
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin Binding FBXO Family Protein Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Coactivator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell-matrix Adhesion Type B Pancreatic Cell Development Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Response To Virus Regulation Of Gene Expression Astrocyte Development Dentate Gyrus Development Lateral Ventricle Development Gliogenesis Cell Dedifferentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Cell Division Regulation Of Cell Cycle Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Liver Development Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Gene Expression Cell Differentiation Lung Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Testosterone Stimulus Cellular Response To Gamma Radiation Response To Fibroblast Growth Factor Positive Regulation Of Neuron Death
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	ERK/MAPK targets NGF-stimulated transcription HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		Alvocidib (2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol Fisetin Palbociclib Ribociclib Abemaciclib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Atrial fibrillation ( 30061737 29892015) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30578418) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 19343178 23563607 31562340 18391950 18391951 18391952) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Ischemic stroke ( 29531354) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 25096241 29403010 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Pulse pressure ( 27841878 27618447 30578418) Red blood cell count ( 29403010 32888494) Rheumatoid arthritis ( 30423114 18794853 24390342) Stroke ( 29531354) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) Total cholesterol levels ( 30275531) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196) White blood cell count ( 25096241 29403010 32888494 20139978 27863252 21738479) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)
Interacting Genes		148 interacting genes: ABI2 ACHE AKT1 ANKRD12 APOBEC1 AR ARAF ARHGEF6 ARNT ATF6B ATXN1 BCL11A BECN1 CASC3 CBLC CBY1 CCND1 CCND2 CCND3 CCNE1 CCNH CCNI CD44 CDC37 CDC6 CDK14 CDK4 CDK7 CDKN1A CDKN2A CDKN2B CDKN2C CDKN2D CLASRP CNOT7 CTNNA1 CTNNB1 DDIT3 DEDD2 EBF4 EIF4ENIF1 ELK1 ELOA2 EPHA2 ERBB2 EZH2 FGFR4 FOXM1 FOXO3 FZR1 GLIS1 GLIS2 GOLGA4 GRM1 H1-1 HGF HIF1A HPD HSF1 ISL1 KAT2A KDELR2 KEAP1 KIF26B KLF10 KRIT1 LATS2 LPIN1 MAP2K3 MAP2K5 MAP3K5 MAPK14 MCM10 MCM2 MEF2D MET MLLT3 MSL3 MYC MZF1 N4BP1 NF2 NFATC3 NIPBL NUMA1 OTP PCNA PDGFRA PML POGZ PPARGC1A PPHLN1 PPM1B PPP2CA PRX PSMA3 RAF1 RASSF1 RB1 RBL1 RBL2 RBM23 RBPMS RGS3 RUNX1 SENP3 SGCE SIRT1 SLBP SNIP1 SORBS1 SOX10 SOX5 SRSF1 SRSF11 SRSF12 SRSF2 SRSF7 SSBP2 STK11 SUMO1 SYNPO2 TAC1 TAL2 TEAD2 TERT TFDP1 TGFBR1 TJP2 TNFRSF1A TP53 TPX2 TRA2A TRA2B TRAK1 TRIM15 TSC1 UHRF2 USP17L2 USP51 VGLL4 ZEB1 ZFP36 ZMYM3 ZNF101 ZNF174 ZNF335 ZSCAN1	43 interacting genes: AKAP8 APP BRCA1 CDK6 CEBPB CREBBP CRK EMX1 EP300 EWSR1 FBXO25 FLI1 FOS GRB10 GRB2 HDAC1 HOXB13 ID1 ID2 ID3 KDM6A KLF4 MAD2L2 MAP2K1 MAP2K3 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MOB4 NFE2L2 PIAS2 PLCG2 SNCA SRF STARD3NL STK16 TAOK2 UBE2I USP17L2
Entrez ID		1021	2002
HPRD ID		04533	02407
Ensembl ID		ENSG00000105810	ENSG00000126767
Uniprot IDs		Q00534	A0A024R1A7 P19419 Q86SR6
PDB IDs		1BI7 1BI8 1BLX 1G3N 1JOW 1XO2 2EUF 2F2C 3NUP 3NUX 4AUA 4EZ5 4TTH 5L2I 5L2S 5L2T 6OQL 6OQO	1DUX 5VVT
Enriched GO Terms of Interacting Partners?
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