G3BP1 and USP10

Number of citations of the paper that reports this interaction (PubMedID 11439350)
69

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		G3BP1	USP10
Description		G3BP stress granule assembly factor 1	ubiquitin specific peptidase 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex Intermediate Filament Cytoskeleton
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Endonuclease Activity Protein Binding ATP Binding ATP Hydrolysis Activity DNA/RNA Helicase Activity	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Transmembrane Transporter Binding
	Biological Process	Ras Protein Signal Transduction Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1
Pathways			Termination of translesion DNA synthesis Ub-specific processing proteases
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)	Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		17 interacting genes: APP CSK DNAH1 DTX1 EPHA8 FBXO25 HAND1 HMGXB3 IL7R LCK LINC01554 OGT PIN1 PPIA RASA1 SYNPO USP10	20 interacting genes: AR G3BP1 H2AC20 HDAC6 IKBKG KLF4 MAP1LC3B MSH2 NOTCH1 PRKAA2 RACK1 RAD51 SCNN1A SCNN1G SIRT6 SMAD4 SNX3 UBC WWTR1 YAP1
Entrez ID		10146	9100
HPRD ID		06569	07029
Ensembl ID		ENSG00000145907	ENSG00000103194
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53	A0A7G6J4N4 Q14694
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5
Enriched GO Terms of Interacting Partners?
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