CDH5 and PARD6A

Number of citations of the paper that reports this interaction (PubMedID 17057644)
43

Data Source:
HPRD (in vitro, in vivo)

		CDH5	PARD6A
Description		cadherin 5	par-6 family cell polarity regulator alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Transmembrane Transporter Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding	Protein Kinase C Binding Protein Binding Transcription Factor Binding GTP-dependent Protein Binding Small GTPase Binding
	Biological Process	Cell Morphogenesis Regulation Of Protein Phosphorylation Vasculature Development Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs		Lenalidomide FX06
Diseases
GWAS		Body size at age 10 ( 32376654) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)	Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		28 interacting genes: CA7 CDH1 CDH16 CDH3 CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR NQO1 P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB PYGB RND3 SHC1 SMG1 SRC VIM	27 interacting genes: APP ATP5MG CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		1003	50855
HPRD ID		03075	06316
Ensembl ID		ENSG00000179776	ENSG00000102981
Uniprot IDs		P33151 Q59EA3	Q9NPB6
PDB IDs			1WMH
Enriched GO Terms of Interacting Partners?
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