CDH5 and RND3

		CDH5	RND3
Description		cadherin 5	Rho family GTPase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Catenin Complex Cell Junction Nuclear Membrane	Golgi Membrane Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Vesicle Cell Projection
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Vascular Endothelial Growth Factor Receptor 2 Binding Transmembrane Transporter Binding Cadherin Binding Fibrinogen Binding BMP Receptor Binding Protein Tyrosine Kinase Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Cell Morphogenesis Regulation Of Protein Phosphorylation Vasculature Development Blood Vessel Maturation Cellular Calcium Ion Homeostasis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Positive Regulation Of Protein Dephosphorylation Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process	Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability	RND3 GTPase cycle
Drugs		Lenalidomide FX06	Guanosine-5'-Triphosphate
Diseases
GWAS		Body size at age 10 ( 32376654) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)	Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Daytime nap ( 33568662) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)
Interacting Genes		28 interacting genes: CA7 CDH1 CDH16 CDH3 CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR NQO1 P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB PYGB RND3 SHC1 SMG1 SRC VIM	10 interacting genes: ARHGAP5 C14orf119 CDH5 CIT CPLANE2 GCH1 PLXNB1 ROCK1 SKP2 UBXN11
Entrez ID		1003	390
HPRD ID		03075	04233
Ensembl ID		ENSG00000179776	ENSG00000115963
Uniprot IDs		P33151 Q59EA3	B2R838 P61587
PDB IDs			1M7B 2V55 4BG6
Enriched GO Terms of Interacting Partners?
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