POM121C and CHRM3

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		POM121C	CHRM3
Description		POM121 transmembrane nucleoporin C	cholinergic receptor muscarinic 3
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Endoplasmic Reticulum Membrane Integral Component Of Membrane Nuclear Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Signaling Receptor Activity Acetylcholine Binding
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus MRNA Transport	Regulation Of Vascular Associated Smooth Muscle Contraction Cellular Protein Modification Process Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Calcium-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Acetylcholine Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Muscarinic acetylcholine receptors Acetylcholine regulates insulin secretion G alpha (q) signalling events
Drugs			Cevimeline Tramadol Succinylcholine Trospium Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Darifenacin Haloperidol Tridihexethyl Anisotropine methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Thiopental Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine Arecoline Mepenzolate ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Diphemanil Aripiprazole lauroxil
Diseases
GWAS		Adult body size ( 32376654) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systolic blood pressure ( 30224653)	Chronic obstructive pulmonary disease ( 30804561) Colorectal cancer ( 29228715) Depression in smokers ( 30219690) Electroencephalogram traits ( 25387704) Feeling worry ( 29500382) FEV1 ( 30804560) Generalized epilepsy ( 22949513) Gut microbiota beta diversity (weighted UniFrac distance) ( 33208821) Hallucinations in long-term cannabis use ( 31740666) Hypertension ( 17554300) Interleukin-6 (red blood cell fatty acid level interaction) ( 28820441) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) Platelet count ( 21507922) Post bronchodilator FEV1 ( 26634245) Reflection (response to stress) ( 30886212) Sulfasalazine-induced agranulocytosis ( 28762467) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		5 interacting genes: APC CHRM3 HINFP MEOX2 STAT5A	26 interacting genes: ARF1 ARF6 BSG CALM3 CCDC184 CD2BP2 COMMD7 CSNK1A1 GNAQ GNAS GPRASP1 GRK6 GZMB JAKMIP1 MAGED2 PDGFRB POM121C PPP1R9B RAB5IF RGS7 SEPTIN3 SET SGSM3 TAP1 TPM3 YIPF3
Entrez ID		100101267	1131
HPRD ID		19406	00329
Ensembl ID		ENSG00000272391	ENSG00000133019
Uniprot IDs		B4DDR5 B4DET5	A0A024R3W1 P20309
PDB IDs			2CSA
Enriched GO Terms of Interacting Partners?
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