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CAPN1 and CAPNS1
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
CAPN1
CAPNS1
Description
calpain 1
calpain small subunit 1
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Cytosol
Plasma Membrane
Membrane
Extracellular Exosome
Molecular Function
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Biological Process
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Extracellular Matrix Disassembly
Receptor Catabolic Process
Neutrophil Degranulation
Regulation Of Catalytic Activity
Mammary Gland Involution
Cornification
Self Proteolysis
Regulation Of NMDA Receptor Activity
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Extracellular Matrix Disassembly
Cornification
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
PD150606
Diseases
GWAS
Urate levels (
31578528
)
Interacting Genes
54 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
20 interacting genes:
AGTRAP
ARHGEF6
ARR3
ATP5MF
CAPN1
CAPN2
CAST
CDC42
CDK4
DRG1
F2RL1
GET4
GNB2
IL2RG
LRRCC1
PPARGC1A
RAB1A
STAT3
TERF1
TRAF5
Entrez ID
823
826
HPRD ID
00253
00240
Ensembl ID
ENSG00000014216
ENSG00000126247
Uniprot IDs
B2RDI5
B4DWH5
P07384
A0A0C4DGQ5
P04632
PDB IDs
1ZCM
2ARY
1KFU
1KFX
4PHJ
4PHK
4PHM
4WQ2
4WQ3
5D69
6QLB
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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