CAPN1 and CLEC4G

Data Source:
BioGRID (two hybrid)

		CAPN1	CLEC4G
Description		calpain 1	C-type lectin domain family 4 member G
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity	Virus Receptor Activity Protein Binding Mannose Binding Polysaccharide Binding Fructose Binding Carbohydrate Derivative Binding Glycosylated Region Protein Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Extracellular Matrix Disassembly Receptor Catabolic Process Neutrophil Degranulation Regulation Of Catalytic Activity Mammary Gland Involution Cornification Self Proteolysis Regulation Of NMDA Receptor Activity	Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of T Cell Proliferation Viral Entry Into Host Cell Regulation Of Immune Response Positive Regulation Of Viral Life Cycle
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Urate levels ( 31578528)	Blood protein levels ( 28240269) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		54 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM	26 interacting genes: APOA1 APOH ARL13B ARSA ASGR1 AZU1 CAPN1 CPLX4 CPN1 EBAG9 EIF6 FAM209A FTL GEM IFI35 LRRC4C MAP3K11 MT-CO1 NUP214 PKLR PRDX1 PTPN5 RPSA SHBG SIGLEC12 WBP2
Entrez ID		823	339390
HPRD ID		00253	16721
Ensembl ID		ENSG00000014216	ENSG00000182566
Uniprot IDs		B2RDI5 B4DWH5 P07384	B7ZKQ2 Q08G24 Q6UXB4 Q6XYD1
PDB IDs		1ZCM 2ARY
Enriched GO Terms of Interacting Partners?
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