LAPTM5 and CYB5R3

Data Source:
BioGRID (two hybrid)

		LAPTM5	CYB5R3
Description		lysosomal protein transmembrane 5	cytochrome b5 reductase 3
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Integral Component Of Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Binding Protein Sequestering Activity	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding Nitrite Reductase (NO-forming) Activity NAD Binding FAD Binding
	Biological Process	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of MAPK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Golgi To Lysosome Transport Positive Regulation Of Lysosomal Membrane Permeability Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation
Pathways			Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases			Methemoglobinemia
GWAS		Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Initial pursuit acceleration ( 29064472)
Interacting Genes		39 interacting genes: AIG1 ANKRD13A C4orf3 CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1	61 interacting genes: ADAM33 AGTRAP AIG1 ALG8 AQP6 ASGR1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PNLIPRP1 REEP4 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 ZDHHC15
Entrez ID		7805	1727
HPRD ID		03280	08942
Ensembl ID		ENSG00000162511	ENSG00000100243
Uniprot IDs		Q13571 Q5TBB8	P00387
PDB IDs			1M91 1UMK
Enriched GO Terms of Interacting Partners?
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