PFN2 and FLT3LG

Data Source:
HPRD (two hybrid)

		PFN2	FLT3LG
Description		profilin 2	fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Integral Component Of Membrane
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	MAPK Cascade Signal Transduction Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	4 interacting genes: FLT3 KITLG KRTAP5-9 PFN2
Entrez ID		5217	2323
HPRD ID		01451	02477
Ensembl ID		ENSG00000070087	ENSG00000090554
Uniprot IDs		P35080	B7ZLY4 M0QYM9 P49771
PDB IDs		1D1J	1ETE 3QS7 3QS9
Enriched GO Terms of Interacting Partners?
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