SUMO2 and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 16524884)
197

Data Source:
BioGRID (pull down, pull down, two hybrid, two hybrid, pull down)

		SUMO2	PIAS2
Description		small ubiquitin like modifier 2	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	Transcription Corepressor Binding RNA Binding Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Gamma glutamyl transferase levels ( 29403010)
Interacting Genes		179 interacting genes: ABRAXAS1 AHNAK ALAS1 ANAPC2 ANXA1 ATF7IP ATRX ATXN7 BABAM2 BAD BAZ1A BAZ1B BLM BRCC3 C18orf25 CAD CARS1 CCNE2 CENPC CHAF1A CHAF1B CHAMP1 CHD3 CHD4 CMTM6 CSNK2B CTNND1 CUL3 CUX1 DAXX DCD DDX17 DDX21 DDX3X DNM1L EEF1A1 EEF1G EGLN3 EME1 ENO1 EP300 ERCC4 EXOSC10 EXOSC9 FOS GATAD2B HDAC1 HDAC2 HDAC4 HDAC9 HIPK2 HNRNPF HNRNPH1 HNRNPK HOMEZ HP1BP3 HSF2 HSP90AB1 HSPA1A HSPA8 HSPA9 IPO5 JUN KALRN KDM1A KIF18B LAS1L LEF1 MAF1 MAST2 MDC1 MDN1 MKI67 MRE11 MSH2 MSX1 MTA1 MTA2 MUS81 MYB NBN NFE2L2 NOL9 NOP2 NUMA1 PARN PELP1 PFKM PHF5A PHF8 PIAS1 PIAS2 PIAS3 PIAS4 PML POGZ PRKDC RAD50 RAD51 RAD54L2 RANBP2 RANGAP1 RBBP4 RBBP7 RCOR1 RCOR2 RCOR3 RNF111 RNF168 RNF216 RNF4 RNF8 RPL3 RPL4 RUVBL1 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SIMC1 SLC22A2 SLX4IP SMCHD1 SOBP SOX10 SOX6 SP100 SSRP1 SUPT16H TDG TDP2 TEAD3 TEX10 TMPO TNIP1 TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TPR TRAF1 TRIM26 TRIM28 TRIM63 TRIML2 TUBA1B TUBB TUBB4B TUBB6 UBA2 UBE2I USP11 USP25 USP28 USP7 USPL1 VIM WRN XRCC5 XRCC6 ZBED1 ZBTB2 ZBTB25 ZBTB33 ZCCHC12 ZCCHC7 ZHX1 ZMAT3 ZMYM3 ZMYM4 ZMYM5 ZNF451 ZNF496	72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451
Entrez ID		6613	9063
HPRD ID		04332	06944
Ensembl ID		ENSG00000188612	ENSG00000078043
Uniprot IDs		A0A024R8S3 P61956	A0A024RC49 O75928 Q2TA77
PDB IDs		1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2N1W 2N9E 2RPQ 3UIN 3UIO 3ZO5 4BKG 4NPN 5D2M 5ELU 5EQL 5GHB 5GHC	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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