PIAS2 and SNAI2

Number of citations of the paper that reports this interaction (PubMedID 30612578)
4

Data Source:
BioGRID (pull down)

		PIAS2	SNAI2
Description		protein inhibitor of activated STAT 2	snail family transcriptional repressor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Notch Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Vitamin D Biosynthetic Process Neural Crest Cell Development Positive Regulation Of Cell Migration Negative Regulation Of Chondrocyte Differentiation Regulation Of Chemokine Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Histone Acetylation Desmosome Disassembly Pigmentation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Fat Cell Differentiation Regulation Of Osteoblast Differentiation White Fat Cell Differentiation Roof Of Mouth Development Epithelium Development Cartilage Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis Notch Signaling Involved In Heart Development Negative Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Stem Cell Proliferation Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			Piebaldism Waardenburg syndrome (WS)
GWAS			Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252)
Interacting Genes		72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451	8 interacting genes: APP PIAS1 PIAS2 PIAS3 PIAS4 SAT1 TRIM23 UBE2I
Entrez ID		9063	6591
HPRD ID		06944	03689
Ensembl ID		ENSG00000078043	ENSG00000019549
Uniprot IDs		A0A024RC49 O75928 Q2TA77	O43623
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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