ATF2 and MAPK13

Number of citations of the paper that reports this interaction (PubMedID 9207191)
75

Data Source:
HPRD (in vitro)

		ATF2	MAPK13
Description		activating transcription factor 2	mitogen-activated protein kinase 13
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Site Of Double-strand Break	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding CAMP Response Element Binding Protein-containing Complex Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Response To Water Deprivation Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Histone Acetylation Intra-S DNA Damage Checkpoint Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Neuron Apoptotic Process Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Adipose Tissue Development Amelogenesis Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process	Response To Osmotic Stress Cell Cycle Regulation Of Gene Expression Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Circadian Clock Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency	NOD1/2 Signaling Pathway p38MAPK events DSCAM interactions VEGFA-VEGFR2 Pathway
Drugs		Pseudoephedrine	KC706
Diseases
GWAS		Intake of total sugars ( 31005972) Metabolite levels ( 23823483)	Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Offspring birth weight ( 31043758)
Interacting Genes		55 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FOS FOSL1 GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PML PRKCE RB1 RPS6KA5 RUVBL2 SMAD3 SMAD4 SRA1 SUMO1 THRB UBE2I UTF1 XPO1 YY1	16 interacting genes: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1
Entrez ID		1386	5603
HPRD ID		00443	09113
Ensembl ID		ENSG00000115966	ENSG00000156711
Uniprot IDs		A4D7V5 P15336	A0A024RD04 O15264
PDB IDs		1BHI 1T2K 4H36	3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
Enriched GO Terms of Interacting Partners?
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