Schizophrenia - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide
HTR2A and ANKS1B	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	ankyrin repeat and sterile alpha motif domain containing 1B	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors		Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Haloperidol Nortriptyline Lisuride Cisapride Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupenthixol Cyclobenzaprine Mesoridazine Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Dihydroergotoxine Yohimbine Methotrimeprazine MMDA 3,4-Methylenedioxymethamphetamine Dimethyltryptamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Iloperidone Sertindole Mianserin Asenapine Amisulpride Cinitapride Lurasidone
HTR2A and NTRK3	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	neurotrophic tyrosine kinase, receptor, type 3	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors		Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Haloperidol Nortriptyline Lisuride Cisapride Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupenthixol Cyclobenzaprine Mesoridazine Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Dihydroergotoxine Yohimbine Methotrimeprazine MMDA 3,4-Methylenedioxymethamphetamine Dimethyltryptamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Iloperidone Sertindole Mianserin Asenapine Amisulpride Cinitapride Lurasidone
DCP2 and DCP1B	decapping mRNA 2	decapping mRNA 1B	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA ATF4 activates genes mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
IRF8 and NFKB1	interferon regulatory factor 8	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Interleukin-1 processing Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex		Thalidomide Pranlukast Triflusal
ID1 and TCF4	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	transcription factor 4	Cellular Senescence Oncogene Induced Senescence	CDO in myogenesis Myogenesis
ID2 and TCF4	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	transcription factor 4		CDO in myogenesis Myogenesis
ID3 and TCF4	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	transcription factor 4		CDO in myogenesis Myogenesis
ID4 and TCF4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	transcription factor 4		CDO in myogenesis Myogenesis
IFRD1 and HDAC4	interferon-related developmental regulator 1	histone deacetylase 4		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
IGF2 and BAG6	insulin-like growth factor 2	BCL2-associated athanogene 6	IRS-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Response to elevated platelet cytosolic Ca2+ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SHC-related events triggered by IGF1R Platelet degranulation Platelet activation, signaling and aggregation IGF1R signaling cascade
IGFBP5 and BAG6	insulin-like growth factor binding protein 5	BCL2-associated athanogene 6	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RBPJ and NOTCH4	recombination signal binding protein for immunoglobulin kappa J region	notch 4	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Regulation of beta-cell development Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Signaling by NOTCH4 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing
IKBKB and NFKB1	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival RIP-mediated NFkB activation via ZBP1 IRAK1 recruits IKK complex Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade TCR signaling Signaling by Interleukins Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling Cytokine Signaling in Immune system MyD88-independent cascade Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Interleukin-1 processing Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Mesalazine Sulfasalazine Auranofin Arsenic trioxide	Thalidomide Pranlukast Triflusal
IL1A and IL1R2	interleukin 1, alpha	interleukin 1 receptor, type II	Signaling by Interleukins Interleukin-1 processing Cellular Senescence Interleukin-1 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
IL1B and IL1R2	interleukin 1, beta	interleukin 1 receptor, type II	Signaling by Interleukins Interleukin-1 processing Interleukin-1 signaling Cytokine Signaling in Immune system	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Minocycline Gallium nitrate Canakinumab Rilonacept
IL1RAP and IL1R2	interleukin 1 receptor accessory protein	interleukin 1 receptor, type II		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
IL1RN and IL1R2	interleukin 1 receptor antagonist	interleukin 1 receptor, type II	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
IL2RA and NFKB1	interleukin 2 receptor, alpha	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Interleukin-1 processing Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Denileukin diftitox Aldesleukin Basiliximab Daclizumab	Thalidomide Pranlukast Triflusal
IL3 and IL3RA	interleukin 3	interleukin 3 receptor, alpha (low affinity)	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Amlexanox	Sargramostim
IL3RA and LNX1	interleukin 3 receptor, alpha (low affinity)	ligand of numb-protein X 1, E3 ubiquitin protein ligase	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling		Sargramostim

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