CDC6 and PSKH1

Number of citations of the paper that reports this interaction (PMID 9889196)
89

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		CDC6	PSKH1
Gene Name		cell division cycle 6	protein serine kinase H1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone	Cellular_component Endoplasmic Reticulum Membrane Golgi Apparatus Microtubule Organizing Center Plasma Membrane Nuclear Speck
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation	Protein Phosphorylation
Pathways		CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1	3 interactors: CDC6 RDH13 SNTA1
Entrez ID		990	5681
HPRD ID		04022	01511
Ensembl ID		ENSG00000094804	ENSG00000159792
Uniprot IDs		Q99741	P11801
PDB IDs		2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process	Regulation Of Vasoconstriction By Circulating Norepinephrine Response To High Light Intensity Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of Peptidyl-cysteine S-nitrosylation Response To Light Intensity DNA Replication Checkpoint Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Chromosome Segregation Ventricular Cardiac Muscle Cell Action Potential Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Membrane Repolarization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Retina Layer Formation Positive Regulation Of Cell Cycle G1/S Phase Transition Cardiac Muscle Cell Action Potential Involved In Contraction Eye Photoreceptor Cell Development Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Positive Regulation Of Cytokinesis Photoreceptor Cell Development Regulation Of Cardiac Muscle Cell Contraction Eye Photoreceptor Cell Differentiation Negative Regulation Of DNA Replication Regulation Of Mitotic Metaphase/anaphase Transition Neuromuscular Junction Development Neural Retina Development Retina Morphogenesis In Camera-type Eye Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Regulation Of Vasoconstriction Regulation Of Cytokinesis Regulation Of Sodium Ion Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Chromosome Segregation Regulation Of Striated Muscle Contraction Action Potential Negative Regulation Of DNA Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Tagcloud ?		antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Difference) ?		antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Intersection) ?