CDC6 and MCM7

Number of citations of the paper that reports this interaction (PMID 10464337)
28

Data Source:
HPRD (in vivo)

		CDC6	MCM7
Gene Name		cell division cycle 6	minichromosome maintenance complex component 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone	Chromatin Nucleoplasm Cytoplasm Cytosol Membrane MCM Complex
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding	DNA Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus
Pathways		CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1	59 interactors: AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC45 CDC6 CDC7 CDK7 CDKN1B CDT1 CRLS1 DBF4 FHL2 GOLGA2 HIF1A HIST3H3 IKBKG INTS6 KIFC3 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RPA1 SMC1A SNTA1 SP2 TCEB1 TREX1 TRIM27 TRIM54 UBE3A UBQLN1 USHBP1
Entrez ID		990	4176
HPRD ID		04022	01154
Ensembl ID		ENSG00000094804	ENSG00000166508
Uniprot IDs		Q99741	C6EMX8 P33993
PDB IDs		2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process DNA Replication Cell Cycle Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Chromosome Organization Regulation Of Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Replication Checkpoint Positive Regulation Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Nucleotide-excision Repair, DNA Damage Removal Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Intracellular Receptor Signaling Pathway Metabolic Process
Tagcloud ?		antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?