MAGI2 and PLXNB3

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		MAGI2	PLXNB3
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 2	plexin B3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Late Endosome Plasma Membrane Tight Junction Postsynaptic Density Dendrite Slit Diaphragm Protein Complex Synapse Perinuclear Region Of Cytoplasm	Intracellular Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity Protein Binding Phosphatase Binding Receptor Signaling Complex Scaffold Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding
	Biological Process	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Cytoplasmic Transport Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Protein Heterooligomerization Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus	Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell Adhesion Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways		Nephrin interactions	Axon guidance Semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Hippocampal atrophy ( 19668339) Obesity-related traits ( 23251661) Response to antidepressant treatment ( 22041458)
Protein-Protein Interactions		15 interactors: ACVR2A ADRB1 ARRDC3 ATN1 BAI1 CTNNB1 CTNND2 DLL1 DSCAML1 GRID2 PLXNB3 PTEN RAPGEF2 SMAD3 TGFA	8 interactors: ARHGEF11 BTBD3 CUL7 CUL9 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		9863	5365
HPRD ID		16212	02198
Ensembl ID		ENSG00000187391	ENSG00000198753
Uniprot IDs		Q86UL8	A8K920 B7Z3H9 Q9ULL4
PDB IDs		1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?		Developmental Process Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis System Development Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Generation Of Neurons Regulation Of Cell Differentiation Organ Development Nervous System Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Neuron Differentiation Embryonic Skeletal System Development Signal Transduction Cell Fate Determination Positive Regulation Of Protein Metabolic Process Cell Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Junction Assembly Signaling Regulation Of Cellular Component Organization Pattern Specification Process Cell Communication Cardiovascular System Development Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Negative Regulation Of Dendrite Morphogenesis Regulation Of Apoptotic Process Regulation Of Postsynaptic Membrane Potential Anterior/posterior Pattern Specification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Embryonic Heart Tube Development Central Nervous System Development Embryonic Pattern Specification Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Ossification	Neurotrophin Signaling Pathway Nervous System Development Cytokinesis Planar Cell Polarity Pathway Involved In Axis Elongation Regulation Of Mitotic Nuclear Division Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Catalytic Activity Generation Of Neurons Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Cellular Response To Organic Substance Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Division Negative Regulation Of Activin Receptor Signaling Pathway Signaling Glomerular Visceral Epithelial Cell Development Cell Communication Positive Regulation Of Cell Projection Organization Positive Regulation Of Hydrolase Activity Cell Cycle Process Cell Morphogenesis Positive Regulation Of Phosphoprotein Phosphatase Activity Nerve Growth Factor Signaling Pathway Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Cytoskeleton Organization Regulation Of Catalytic Activity Positive Regulation Of Neuron Differentiation Anatomical Structure Morphogenesis Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Differentiation System Development Response To Organic Substance Positive Regulation Of Receptor Internalization Positive Regulation Of Cellular Metabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Cellular Response To Stimulus Regulation Of Activin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Positive Regulation Of Neurogenesis Cell Cycle Cell Division Microtubule Cytoskeleton Organization
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	alias amplifications bgn casp9 ccnc cgh e2f5 eck efnb3 epha2 ercc1 fgf3 fgr frap1 hspg2 il12a l1cam lamc1 mexican nonaffected outline pctk2 pctk3 plexr tnfrsf10a tnfrsf10b tp73 turned underexpressed
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	alias amplifications bgn casp9 ccnc e2f5 eck efnb3 epha2 ercc1 fgf3 fgr frap1 hspg2 il12a l1cam lamc1 mexican nonaffected outline pctk2 pctk3 plexr tnfrsf10a tnfrsf10b tp73 turned underexpressed
Tagcloud (Intersection) ?		cgh