MAGI2 and GRID2

Number of citations of the paper that reports this interaction (PMID 12589829)
4

Data Source:
HPRD (two hybrid, in vivo)

		MAGI2	GRID2
Gene Name		membrane associated guanylate kinase, WW and PDZ domain containing 2	glutamate receptor, ionotropic, delta 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Late Endosome Plasma Membrane Tight Junction Postsynaptic Density Dendrite Slit Diaphragm Protein Complex Synapse Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Ionotropic Glutamate Receptor Complex Cell Junction Dendrite Dendritic Spine Synapse Postsynaptic Membrane
	Molecular Function	Signal Transducer Activity Protein Binding Phosphatase Binding Receptor Signaling Complex Scaffold Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding	Ionotropic Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Glutamate Receptor Activity PDZ Domain Binding Scaffold Protein Binding
	Biological Process	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Cytoplasmic Transport Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Protein Heterooligomerization Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus	Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Ion Transmembrane Transport Cellular Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition
Pathways		Nephrin interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Hippocampal atrophy ( 19668339) Obesity-related traits ( 23251661) Response to antidepressant treatment ( 22041458)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: ACVR2A ADRB1 ARRDC3 ATN1 BAI1 CTNNB1 CTNND2 DLL1 DSCAML1 GRID2 PLXNB3 PTEN RAPGEF2 SMAD3 TGFA	10 interactors: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4
Entrez ID		9863	2895
HPRD ID		16212	06781
Ensembl ID		ENSG00000187391	ENSG00000152208
Uniprot IDs		Q86UL8	E9PH24 O43424
PDB IDs		1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?		Developmental Process Multicellular Organismal Development Anatomical Structure Development Anatomical Structure Morphogenesis System Development Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Epithelial Cell Proliferation Regulation Of Cell Adhesion Generation Of Neurons Regulation Of Cell Differentiation Organ Development Nervous System Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Neuron Differentiation Embryonic Skeletal System Development Signal Transduction Cell Fate Determination Positive Regulation Of Protein Metabolic Process Cell Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Junction Assembly Signaling Regulation Of Cellular Component Organization Pattern Specification Process Cell Communication Cardiovascular System Development Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process Negative Regulation Of Dendrite Morphogenesis Regulation Of Apoptotic Process Regulation Of Postsynaptic Membrane Potential Anterior/posterior Pattern Specification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Embryonic Heart Tube Development Central Nervous System Development Embryonic Pattern Specification Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Ossification	Receptor Clustering Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Cellular Protein Localization Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Localization To Membrane Regulation Of Vesicle-mediated Transport Long Term Synaptic Depression Maintenance Of Protein Location In Cell Maintenance Of Protein Location Maintenance Of Location In Cell Regulation Of Synaptic Plasticity Protein Localization Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Transport Cellular Localization Positive Regulation Of Neuron Apoptotic Process Membrane Organization Cellular Response To Glucose Stimulus Regulation Of Neurotransmitter Secretion Cell-cell Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Neuron Death Regulation Of Postsynaptic Membrane Potential Cytoplasmic Sequestering Of CFTR Protein Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Regulation Of Phosphatase Activity Planar Cell Polarity Pathway Involved In Axis Elongation Negative Regulation Of Signaling Membrane Depolarization Protein Localization To Endoplasmic Reticulum Regulation Of Dephosphorylation Response To Glucose Regulation Of Exocytosis Intracellular Transport Cytoplasmic Transport Response To Carbohydrate Negative Regulation Of Golgi To Plasma Membrane Protein Transport Glucose Homeostasis
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	4q ataxia atrophy biallelic cerebella cerebellar cerebellum deletions evolutionarily exon eye fibers genotyping heterozygous homozygosity homozygous linkage movement movements ortholog purkinje recordings resemblance sanger speech spines synapse tonic upgaze
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28	4q ataxia atrophy biallelic cerebella cerebellar cerebellum deletions evolutionarily exon eye fibers genotyping heterozygous homozygosity homozygous linkage movement movements ortholog purkinje recordings resemblance sanger speech spines synapse tonic upgaze
Tagcloud (Intersection) ?