RB1CC1 and TBKBP1

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RB1CC1	TBKBP1
Gene Name		RB1-inducible coiled-coil 1	TBK1 binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Membrane Pre-autophagosomal Structure Membrane ATG1/UKL1 Signaling Complex ULK1-ATG13-FIP200 Complex
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Autophagic Vacuole Assembly Liver Development Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle JNK Cascade Heart Development Regulation Of Autophagy Positive Regulation Of Cell Size Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Innate Immune Response
Pathways
Drugs
Diseases
GWAS			Ankylosing spondylitis ( 21743469) Multiple sclerosis ( 22190364)
Protein-Protein Interactions		9 interactors: CALCOCO2 EXOC1 GABARAP PTK2 PTK2B RFWD2 TBKBP1 UBC VHL	3 interactors: AGO2 APBA3 RB1CC1
Entrez ID		9821	9755
HPRD ID		06019	12239
Ensembl ID		ENSG00000023287	ENSG00000198933
Uniprot IDs		Q8TDY2	A7MCY6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Stress Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Signal Complex Assembly Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Protein Ubiquitination Immune Response Defense Response Regulation Of Proteolysis Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphatidylinositol 3-kinase Activity Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Lipid Kinase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Negative Regulation Of Apoptotic Process Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Programmed Cell Death Endothelial Cell Migration Apoptotic Process Negative Regulation Of Cell Death Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Programmed Cell Death Positive Regulation Of Cell Cycle Arrest Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Death Response To Abiotic Stimulus Epithelial Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Epithelium Migration Signal Transduction In Response To DNA Damage Immune System Process Positive Regulation Of Protein Kinase Activity Mitotic DNA Damage Checkpoint	MRNA Cleavage Involved In Gene Silencing By MiRNA SiRNA Loading Onto RISC Involved In RNA Interference Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA 3'-end Processing MiRNA Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cell Size RNA Interference Pre-miRNA Processing Regulation Of MRNA 3'-end Processing MRNA Cleavage Negative Regulation Of Translational Initiation Positive Regulation Of MRNA Catabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Silencing By MiRNA Cellular Response To DsRNA Posttranscriptional Gene Silencing Autophagic Vacuole Assembly Macroautophagy Gene Silencing By RNA Multicellular Organismal Development
Tagcloud ?		bag3 broiler chicken chickens clusters cytoskeleton degs depth differentially discovered enrichment exact exploited fully gallus heat hsp25 hsph1 hunger id1 leg microarrays modules networks pdk qrt suffering thermoregulation yellow	activator ag azacytidine azi2 cdcs clarified critical csf cycling dcs defects dendritic dispensable efficiency efficient generation gm ifn ifns immunization marrow member nap1 none production reciprocally tank tbk1 tnfr
Tagcloud (Difference) ?		bag3 broiler chicken chickens clusters cytoskeleton degs depth differentially discovered enrichment exact exploited fully gallus heat hsp25 hsph1 hunger id1 leg microarrays modules networks pdk qrt suffering thermoregulation yellow	activator ag azacytidine azi2 cdcs clarified critical csf cycling dcs defects dendritic dispensable efficiency efficient generation gm ifn ifns immunization marrow member nap1 none production reciprocally tank tbk1 tnfr
Tagcloud (Intersection) ?