SNX17 and VLDLR

Number of citations of the paper that reports this interaction (PMID 12169628)
26

Data Source:
HPRD (in vitro, in vivo)

		SNX17	VLDLR
Gene Name		sorting nexin 17	very low density lipoprotein receptor
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle Protein Complex	Plasma Membrane Coated Pit Membrane Integral Component Of Membrane Very-low-density Lipoprotein Particle Receptor Complex
	Molecular Function	Receptor Binding Protein Binding Protein C-terminus Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding	Glycoprotein Binding Low-density Lipoprotein Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Glycoprotein Transporter Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Endosomal Transport Regulation Of Endocytosis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Lipid Transport Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Dendrite Development
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease (age of onset) ( 22005931) Gambling ( 22780124) Vascular endothelial growth factor levels ( 21757650)
Protein-Protein Interactions		10 interactors: APP HRAS LDLR LRP1 LRP2 LRP8 RLIM SELP SKIL VLDLR	9 interactors: APOE CD36 CLU DAB1 LPL LRPAP1 MYLIP RELN SNX17
Entrez ID		9784	7436
HPRD ID		05812	01895
Ensembl ID		ENSG00000115234	ENSG00000147852
Uniprot IDs		B4DQ37 B4DTB8 Q15036	P98155 Q5VVF5
PDB IDs		3FOG 3LUI 4GXB	1V9U 3DPR
Enriched GO Terms of Interacting Partners?		Endocytosis Response To Light Stimulus Vesicle-mediated Transport Response To Radiation Phototransduction, Visible Light Retinoid Metabolic Process Steroid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Alcohol Metabolic Process Receptor-mediated Endocytosis Sterol Metabolic Process Detection Of Abiotic Stimulus Response To External Stimulus Response To Abiotic Stimulus Reelin-mediated Signaling Pathway Positive Regulation Of Cell Projection Organization Lipid Metabolic Process Nervous System Development Blood Coagulation Hemostasis Central Nervous System Development System Development Regulation Of Cell Projection Organization Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Regulation Of Cellular Component Organization Regulation Of Neuron Differentiation Detection Of Stimulus Regulation Of Body Fluid Levels Behavior Wound Healing Multicellular Organismal Development Positive Regulation Of Neuron Projection Development Plasma Lipoprotein Particle Clearance Anatomical Structure Development Negative Regulation Of Gene Expression Transport Response To Wounding Regulation Of Neurogenesis Learning Or Memory Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Wound Healing Brain Development	Regulation Of Beta-amyloid Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Lateral Motor Column Neuron Migration Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Cholesterol Transport Sterol Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Inclusion Body Assembly Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Beta-amyloid Formation Triglyceride-rich Lipoprotein Particle Remodeling Receptor-mediated Endocytosis CGMP-mediated Signaling Cholesterol Catabolic Process Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Cell Differentiation Lipid Homeostasis Positive Regulation Of Cholesterol Storage Negative Regulation Of Amyloid Precursor Protein Catabolic Process Nitric Oxide Mediated Signal Transduction Regulation Of Beta-amyloid Formation Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Triglyceride Catabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Steroid Catabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Acylglycerol Catabolic Process Glial Cell Differentiation Plasma Lipoprotein Particle Remodeling Regulation Of Protein Metabolic Process Positive Regulation Of Dendritic Spine Development Lipid Metabolic Process Positive Regulation Of Lipid Storage Postsynaptic Membrane Organization Regulation Of Phosphorylation Plasma Lipoprotein Particle Clearance Cyclic-nucleotide-mediated Signaling Positive Regulation Of Protein Catabolic Process Endocytosis Cellular Localization Gliogenesis
Tagcloud ?		1x10 a2ic aa2t abi analyzer bait bigdye ccdc32 gal gal4 heterotetramer lexa ligated monocyte ncbi nlm ogdh papd4 pbtm116 plasmin prey prism procathepsin ready reconstituting resultant rps2 terminator zbtb4	1alpha ag basel chip display elucidated endothelial enhancement hampered hif huvecs hypoxia immunoblot karger luciferase markedly mimicked pretreated pretreatment protection protects recruitment robust sala salvianolic suppressing umbilical vein
Tagcloud (Difference) ?		1x10 a2ic aa2t abi analyzer bait bigdye ccdc32 gal gal4 heterotetramer lexa ligated monocyte ncbi nlm ogdh papd4 pbtm116 plasmin prey prism procathepsin ready reconstituting resultant rps2 terminator zbtb4	1alpha ag basel chip display elucidated endothelial enhancement hampered hif huvecs hypoxia immunoblot karger luciferase markedly mimicked pretreated pretreatment protection protects recruitment robust sala salvianolic suppressing umbilical vein
Tagcloud (Intersection) ?